X-Ray- and Neutron-Scattering Studies of -Crystallin and Evidence That the Target Protein Sits in the Fenestrations of the -Crystallin Shell
نویسندگان
چکیده
CONCLUSIONS. Bovine lens -crystallin in solution can be modeled as a fenestrated spherical shell of diameter 169 Å. At physiological temperatures, a weak interaction between and -crystallin occurs, and -crystallin is located in the fenestrations. Deuterium substitution indicates that the superaggregation process is controlled by hydrogen bonding. However, the chaperone process and superaggregation appear not to be linked. (Invest Ophthalmol Vis Sci. 2007;48:2695–2700) DOI: 10.1167/iovs.06-0559
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